La Crosse virus (LACV) is one of the California serogroup viruses which may be transmitted to humans by infected mosquitoes. LACV may be identified in cases where aseptic meningitis or encephalitis of unknown origin are identified. LACV affects ~80 people in the eastern US every year, primarily children aged 16 and younger living in the Appalachian region. It may cause severe neuroinvasive diseases that regularly result in long-term cognitive disorders that impede neurological development.